Table 3. Cytotoxic effect of polycerasoidin against breast cancer cells.
| Cell line | IC50 (μg/ml) | |||||
|---|---|---|---|---|---|---|
| Polycerasoidin 12 h | Tamoxifen 12 h | Polycerasoidin 24 h | Tamoxifen 24 h | Polycerasoidin 48 h | Tamoxifen 48 h | |
| MCF7 (μg/ml) | 8.25 ± 0.59 | 3.24 ± 0.37 | 4.91 ± 0.46 | 2.03 ± 0.58 | 3.16 ± 0.31 | 1.5 ± 0.22 |
| MCF7 (μM) | 22.16 ± 1.58 | 8.24 ± 0.99 | 13.19 ± 1.23 | 5.46 ± 1.56 | 8.48 ± 0.83 | 4.03 ± 0.59 |
| LA7 (μg/ml) | 6.47 ± 0.96 | 4.61 ± 0.84 | 4.38 ± 0.77 | 2.81 ± 0.83 | 2.69 ± 0.57 | 1.62 ± 0.25 |
| LA7 (μM) | 17.38 ± 2.57 | 12.40 ± 2.26 | 11.76 ± 2.06 | 7.56 ± 2.23 | 7.22 ± 1.53 | 4.36 ± 0.67 |
| MCF10A(μg/ml) | 82.28 ± 3.37 | 75.24 ± 4.32 | 77.23 ± 2.76 | 62.68 ± 3.51 | 59.31 ± 2.38 | 35.13 ± 2.71 |
| MCF10A (μM) | 221.04 ± 9.05 | 202.52 ± 11.62 | 207.47 ± 7.41 | 168.71 ± 9.44 | 159.33 ± 6.39 | 94.55 ± 7.29 |
The data are shown as the means ± SEM.
The IC50 concentration was calculated after exposure of the cells to polycerasoidin or tamoxifen (positive control) for 12, 24 and 48 h.