Table 2.
Unadjusted participant performance on neurocognitive tests
| Test | First test (n = 40) | Second test (n = 40) | p value | Before HD (n = 40) | During HD (n = 40) | p value |
|---|---|---|---|---|---|---|
| MMSE | 26.7 ± 2.6 | 27.0 ± 2.6 | 0.4 | 26.9 ± 2.6 | 26.8 ± 2.6 | 0.8 |
| Verbal IQ (NAART) | 102.8 ± 14.2 | 102.9 ± 13.6 | 0.8 | 102.5 ± 14.3 | 103.2 ± 13.4 | 0.2 |
| Word List Learning | ||||||
| Delayed Recall | 4.5 ± 2.5 | 5.4 ± 3.1 | 0.003 | 5.0 ± 2.9 | 4.9 ± 2.8 | 0.8 |
| Total Recall | 24.6 ± 6.8 | 27.5 ± 7.7 | <0.001 | 25.9 ± 7.3 | 26.2 ± 7.5 | 0.7 |
| Recognition | 20.5 ± 2.8 | 20.6 ± 3.0 | 0.8 | 20.8 ± 2.9 | 20.4 ± 2.8 | 0.4 |
| Block Design | 26.7 ± 12.0 | 28.0 ± 10.5 | 0.07 | 27.2 ± 11.8 | 27.6 ± 10.7 | 0.9 |
| Digit Span | ||||||
| Digits Forward | 10.5 ± 2.2 | 10.2 ± 2.3 | 0.3 | 10.2 ± 2.2 | 10.4 ± 2.4 | 0.4 |
| Digits Backward | 5.7 ± 2.1 | 5.7 ± 2.0 | 0.9 | 5.8 ± 1.9 | 5.6 ± 2.2 | 0.7 |
| Digit Symbol Substitution | 45.2 ± 17.4 | 48.4 ± 19.8 | 0.02 | 47.6 ± 17.4 | 45.9 ± 19.9 | 0.2 |
| Trail Making Tests | ||||||
| Trails A, s | 58.9 ± 40.8 | 56.6 ± 47.9 | 0.6 | 57.2 ± 40.8 | 58.3 ± 48.0 | 0.8 |
| Trails B, s | 138.1 ± 82.9 | 136.8 ± 83.7 | 0.9 | 132.6 ± 83.8 | 142.3 ± 82.5 | 0.3 |
| Mental Alternation | 22.2 ± 9.3 | 22.5 ± 8.8 | 0.6 | 22.7 ± 8.0 | 22.0 ± 9.9 | 0.4 |
| COWAT | ||||||
| Animals | 16.9 ± 5.4 | 17.8 ± 6.4 | 0.3 | 17.5 ± 5.3 | 17.1 ± 6.6 | 0.6 |
| Supermarket Items | 22.9 ± 6.6 | 22.2 ± 7.9 | 0.6 | 23.0 ± 6.5 | 22.1 ± 7.9 | 0.4 |
All scores are the number correct, with higher values indicating better performance, except for the Trail Making Tests, where higher time to complete identifies worse performance. Scores are for the specified groups (each participant appears twice) and are not adjusted for the timing or period of testing.