Table 5.

Summary of cannabis as a potential treatment option for diabetic peripheral neuropathy [63–65, 69, 70]

Treatment	Mechanism of action	Advantages	Disadvantages
Cannabinoids
Cannabis	Partial cannabinoid receptor agonist	• Smoked cannabis relieves HIV-associated neuropathy	• Not FDA-approved for pDPN • Side effects include headache, dizziness, somnolence, dry mouth, constipation, and diarrhea • Cannabis spray showed no effect on painful polyneuropathy • Medicolegal and regulatory hurdles • Social stigma

FDA Food and Drug Administration, HIV human immunodeficiency virus, pDPN painful diabetic peripheral neuropathy