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Muscarinic acetylcholine receptor signaling functions as an autophagy-inducing signaling pathway. In the simplified model shown, starvation activates MAPK (MPK-1, C. elegans ortholog of mammalian ERK) through the muscarinic acetylcholine receptor signaling pathway. Activated MAPK positively regulates autophagy, at least in part, through DAP kinase and RGS-2.
