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. 2015 May 15;49(3):236–242. doi: 10.4132/jptm.2015.03.16

Fig. 3.

Fig. 3.

In HER2 dual color silver in situ hybridization study, almost every nucleus in cases of EDTA protocol demonstrates two intact signals of HER2 and CEP17, while cases of RDO or HCl protocol barely demonstrate HER2 or CEP17 signals from the nucleus due to the severe breakdown of DNA (A, B, comparison of EDTA versus HCl in a pair of bone marrow from the same patients; C, D, comparison of RDO versus HCl in a pair of bone marrow from the same patients). EDTA, ethylenediaminetetraacetic acid disodium salt dehydrate; RDO, RDO GOLD; HCl, hydrochloric acid.