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. 2015 May 15;49(3):236–242. doi: 10.4132/jptm.2015.03.16

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© 2015 The Korean Society of Pathologists/The Korean Society for Cytopathology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4. — The quality of RNA is compared in kappa light chain (A–D) and lambda light chain (E–H) RNA in situ hybridization using a pair of bone marrow specimens from the same patient. In a case of kappa light chain-restricted plasma cell myeloma, EDTA protocol (A) reveals intact quality while HCl (B) protocol shows poor quality in kappa light chain RNA in situ hybridization. In a case of lambda light chain-restricted plasma cell myeloma, EDTA protocol (E) reveals intact quality while HCl (F) protocol shows poor quality. In a case of polyclonal plasma cell infiltration within the bone marrow, the EDTA and RDO protocol (C and G, respectively) reveal intact quality while HCl (D, H) protocol show poor quality in kappa and lambda light chain RNA in situ hybridization, respectively. EDTA, ethylenediaminetetraacetic acid disodium salt dehydrate; HCl, hydrochloric acid; RDO, RDO GOLD.