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. 2015 Jun 1;25(3):113–120. doi: 10.1089/nat.2014.0527

FIG. 1.

FIG. 1.

Design and targeting of single stranded silencing RNAs (ss-siRNAs). (A) ss-siRNA 642661 possess a typical pattern of chemical modifications. Positions of chemical modifications within the sequence are indicated as follows: 2′-O-me (methyl) modified base is background shaded; 2′-O-MOE (methoxyethyl) modified base is boxed; 2′-Fluoro modified base is underlined; mismatched base is bold and italicized; phosphorothioate (PS) linkage is shown as subscript (s). The terminal thymidine has a 5′- phosphate. All other linkages are phosphate. (B) Schematic showing splicing of dystrophin pre-mRNA and how splicing might be modified by a RNA acting through the RNA interference (RNAi) pathway and argonaute 2 (Ago2).