. Author manuscript; available in PMC: 2015 May 22.

Published in final edited form as: Behav Genet. 2013 Aug 23;43(5):402–414. doi: 10.1007/s10519-013-9607-9

Table 3.

Random-effects logistic regression of alcohol dependence on the interaction of GABRA2 genotype (SNP rs279871), gender, and daily uplifts, COGA (n = 2,281)

	Model I OR (95 % CI)	Model II OR (95 % CI)	Model III OR (95 % CI)
High risk genotype	1.29 (1.02–1.62)^*	1.66 (0.96–2.84)
Female	0.20 (0.16–0.25)^***	0.20 (0.16–0.25)^***	0.26 (0.14–0.48)^***
Age (10 years)	0.97 (0.90–1.05)	0.97 (0.90–1.05)	0.97 (0.89–1.05)
Education (years)	0.87 (0.83–0.92)^***	0.87 (0.83–0.92)^***	0.87 (0.83–0.92)^***
Currently married	0.68 (0.53–0.87)^**	0.68 (0.53–0.87)^**	0.67 (0.52–0.86)^**
Log of HH income ($10K)	0.91 (0.83–0.99)^*	0.91 (0.83–0.99)^*	0.91 (0.83–0.996)^*
Daily hassles	2.45 (1.86–3.23)^***	2.46 (1.86–3.24)^***	2.47 (1.87–3.26)^***
Daily uplifts	0.85 (0.67–1.08)
Interactions
Uplifts* high risk genotype		0.77 (0.47–1.27)
Uplifts* low risk genotype		0.92 (0.69–1.23)
High risk genotype* female			0.79 (0.35–1.77)
High risk genotype* male			3.30 (1.54–7.06)^***
Uplifts* female* high risk genotype			1.02 (0.56–1.87)
Uplifts* male* high risk genotype			0.51 (0.28–0.91)^*
Uplifts* female* low risk genotype			0.90 (0.58–1.38)
Uplifts* male* low risk genotype			0.94 (0.64–1.37)
Intra-class correlation	0.23	0.23	0.23
Wald X²	263.18^***	263.87^***	269.92^***

OR odds ratio, CI confidence interval

p < 0.05;

^**

p < 0.01;

^***

p < 0.001