Table 1. Distribution of FV vector integration sites in the human genome.
Integration sites within | FV (n = 799) | Random (n = 799)a | P value |
---|---|---|---|
Gene (%) | 40.1 | 45.4 | 0.034 |
Exon (%) | 3.1 | 2.8 | 0.77 |
Intron (%) | 36.9 | 42.7 | 0.021 |
Gene upstream (≤30 kb, %) | 33.9 | 20.4 | 1.53 × 10−9 |
Gene downstream (≤30 kb, %) | 24.8 | 20.0 | 0.026 |
P value of ≤ 0.01 was considered statistically significant.
Average of three size-matched sets of 799 random sites.