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. 2015 May 22;5:10535. doi: 10.1038/srep10535

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(A) TUNEL and DAPI staining in the cortex for Dicer cKO mice. TUNEL+(a,d,g,j) cells were shown in green and DAPI+(b,e,h,k) cells in blue (a-f: control; g-l: cKO). TUNEL+cells were hardly found in control mice (a,d), but were readily seen in Dicer cKO (g,j) mice. Scale bar = 25 μm. (B) Quantitative results on the average number of TUNEL+cells in the cortex per section. Dicer cKO mice exhibited>60 TUNEL+cells in average, and were significantly different from controls (p < 0.001). Minocycline did not change the total number of TUNEL+cells. (C) Quantitative results on the average number of TUNEL+cells in the hippocampus per section. Dicer cKOs showed significantly more number of TUNEL+cells than controls did (p < 0.001).