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. 2015 May 22;5:10510. doi: 10.1038/srep10510

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Polymorphism of the residue 383 and the residue 224 in the PA protein of influenza A viruses. A total of 10524 PA sequences from avian isolates (all subtypes) and a total of 7252 PA sequences from human isolates (H1, H2, H3 subtypes, excluding pdmH1N1) were aligned for analyzing the polymorphism of PA 383 residue in avian species and humans. Additionally, all the available PA sequences (a total of 24981) of influenza A viruses were aligned the polymorphism of PA 224 residue. Highly pathogenic signature PA/224P mostly exists in H5N1 and pdmH1N1 subtypes of influenza viruses. Sequence search and alignment were performed by the online service of the Influenza Research Database ( http://www.fludb.org), in October 2014.