Table 1. Replication of H5N1 avian influenza viruses in mice.
| Virus |
Virus replication on day 3 p.i. (log10EID50/ml ± SD) |
|||
|---|---|---|---|---|
| Lung | Spleen | Kidney | Brain | |
| R-DK/49 | 7.7 ± 0.1 | 3.6 ± 0.1 | 2.8 ± 0.6 | 3.1 ± 1.2 |
| DK/49-PA224S | 7.4 ± 0.1 | 4.8 ± 0.0 | 3.3 ± 0.5 | 2.8 ± 0.4 |
| DK/49-PA383N | 7.4 ± 0.1 | 4.3 ± 0.7 | 3.5 ± 1.1 | 3.2 ± 1.3 |
| DK/49-PA224S + 383N | 7.5 ± 0.3 | 3.6 ± 0.1 | 2.3 ± 0.4 | 1.4 ± 0.8 |
| R-GS/65 | 5.0 ± 0.4 | < | < | < |
| GS/65-PA224P | 4.9 ± 0.3 | 1.8 ± 0.6 | 1.5 ± 1.4 | 1.0 ± 0.9 |
| GS/65-PA383D | 5.3 ± 0.1 | 0.8 ± 1.3 | < | 1.3 ± 0.5 |
| GS/65-PA224P + 383D | 6.8 ± 0.4 | 3.1 ± 1.0 | 2.3±1.4 | 2.5 ± 1.1 |
<, Not detectable.