Table 1.

Advantages and disadvantages of rat defect models

Defect Type	Advantages	Disadvantages
Fenestration (periodontal)	gives a proof-of-concept in a short interval well-contained defects no gingival tissue ingrowth	narrow healing window small size, surgical microscopes required spontaneous healing
Capsule (vertical ridge)	standardized shape-dimension shielded from local environment filled solely with cells and fluids emanating from the residual bone	not applicable to alveolar bone isolation from oral environment spontaneous regeneration formation of bone outside the capsule
Alveolar socket	easy and fast to perform reproduce well the events occurring in bone healing	small size rapid bone repair compared to human
Infrabony peri-implant defect	Surgically created short-time needed to be generated defect standard morphology-dimension	Surgically created spontaneous regeneration narrow evaluation window

Reproduced from (95), with permission.