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. 2015 Apr 1;46(6):2629–2638. doi: 10.3892/ijo.2015.2946

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Copyright © 2015, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Nobiletin inhibits tumor growth and angiogenesis in CAM and athymic mouse models. Chicken chorioallantoic membrane (CAM) assay showing tumor without nobiletin treatment (A), treated with 20 μM nobiletin (B). CAM assays showed that 20 μM nobiletin suppressed the growth of blood vessels and A2780/CP70 tumors xenografted on chicken CAM relative to vehicle treated tumors (C). After 5 days of treatment, the tumors were excised, and the blood vessels were counted by phase contrast microscopy. Angiogenesis was evaluated by normalizing number of branching vessels to that of control CAM. The data are presented as mean ± SEM (n=10 eggs/group) (C). Nobiletin treatment also significantly inhibited tumor growth in the athymic mice (D).