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. 2015 Apr 1;46(6):2656–2662. doi: 10.3892/ijo.2015.2945

Figure 4.

Figure 4

p53 increases CADM1 expression. The CADM1 protein was upregulated by exogenous p53 in a dose-dependent manner in keratinocytes and various cancer cells, including HPV-negative C33A and HPV-positive SiHa cells. After individual cells were transfected with various concentrations of pcDNA3.1-flag-p53 for 48 h, the cells were harvested for western blot analysis of the expression level of CADM1 and exogenous p53 in transfected cells. The expression level of the β-actin protein was considered as the loading control.