Table 1.
Frequency of positive cases and methylation levels [Median (IQR, Interquartile Range)] in Atypical Ductal Hyperplasia (ADH), Ductal Carcinoma in situ (DCIS) Invasive Ductal carcinoma (IDC) and Normal Breast Tissue (NBT)
| Genes | ADH(n=21) | DCIS(n=32) | IDC(n=43) | NBT(n=20) | P* | ||||
|---|---|---|---|---|---|---|---|---|---|
| n (%) | Median (IQR) | n (%) | Median (IQR) | n (%) | Median (IQR) | n (%) | Median (IQR) | ||
| APC | 13 (65) | 16.66 (0–762.38) | 23 (72) | 167.08 (0–731.54) | 36 (84) | 157.44 (0.29–818.25) | 3 (15) | 0 (0-0) | P<0.0001 |
| CDH1 | 7 (35) | 0 (0–32.21) | 16 (50) | 0.43 (0–8.89) | 28 (65) | 4.70 (0–25.13) | 3 (15) | 0 (0-0) | P<0.004 |
| CTNNB1 | 4 (19) | 0 (0-0) | 11 (34) | 0 (0–2.27) | 19 (44) | 0 (0–3.33) | 2 (10) | 0 (0-0) | P<0.05 |
| ESR1 | 10 (48) | 6.55 (0–11.40) | 11 (34) | 0 (0–14.04) | 21 (51) | 0.41 (0–12.96) | 8 (40) | 0 (0–22.09) | P=NS |
| TIMP3 | 13 (62) | 6.50 (0–47.05) | 14 (44) | 0 (0–11.23) | 24 (56) | 5.31 (0–48.56) | 9 (45) | 0 (0–87.51) | P=NS |
| GSTPI | 2 (10) | 0 (0-0) | 5 (16) | 0 (0–0.75) | 8 (19) | 0 (0-0) | 1 (5) | 0 (0-0) | P=NS |
| MGMT | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | NA |
| THBS1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | NA |
| TMS1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | NA |
*
NA, Not applicable; NS, not significant.