Figure 4. Transcriptional controls of multiciliogenesis.
The transcriptional cascade leading to the generation of MCC axonemal tufts is outlined for mucocilairy MCCs (i.e. the mammalian airway and the Xenopus epidermis) and for ependymal MCCs. Solid lines represent direct interactions, dashed lines represent indirect (or unknown) interactions. Selected known target genes are written in italics, and labeled with the color of the transcription factor controlling them. Asterisk indicates that connection is only known for mucuociliary cells.