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Lack of ESAM attenuates platelet disaggregation. Platelet aggregation was performed using platelets from wild-type or ESAM−/− mice with ADP (2 μM) as the agonist. Following peak aggregation, either apyrase (0.2 U mL−1, left) or tirofiban (0.5 μM, right) was added to induce disaggregation at the time point indicated by the arrowheads. Arrows indicate addition of ADP.
