Table 2.
Types of Cell Foci in CMV/Cux-1 Transgenic and Non-transgenic Livers
| Type | 8 months | 10 months | 14 months | |
|---|---|---|---|---|
| CMV/Cux-1 transgenic | ||||
| Female | ||||
| Inflammation (non-suppurative) | 4 (6) | 3 (5) | 3 (3) | |
| Mixed cell foci | 0 (6) | 3 (5) | 2 (3) | |
| Oval cell hyperplasia | 0 (6) | 0 (5) | 1 (3) | |
| Hepatocellular carcinoma | 0 (6) | 0 (5) | 1 (3) | |
| Male | ||||
| Inflammation (non-suppurative) | 3 (4) | 4 (4) | 3 (3) | |
| Mixed cell foci | 1 (4) | 4 (4) | 3 (3) | |
| Oval cell hyperplasia | 0 (4) | 0 (4) | 1 (3) | |
| Hepatocellular carcinoma | 0 (4) | 1 (4) | 2 (3) | |
| Non-transgenic | ||||
| Female | ||||
| Inflammation (non-suppurative) | 0 (5) | 1 (6) | 0 (3) | |
| Mixed cell foci | 0 (5) | 1 (6) | 0 (3) | |
| Oval cell hyperplasia | 0 (5) | 1 (6) | 0 (3) | |
| Hepatocellular carcinoma | 0 (5) | 1 (6) | 0 (3) | |
| Male | ||||
| Inflammation (non-suppurative) | 0 (3) | 1 (4) | 0 (3) | |
| Mixed cell foci | 0 (3) | 1 (4) | 0 (3) | |
| Oval cell hyperplasia | 0 (3) | 0 (4) | 0 (3) | |
| Hepatocellular carcinoma | 0 (3) | 1 (4) | 0 (3) | |
Summarized numbers of animals exhibiting preneoplastic lesions and hepatocellular carcinoma in H&E sections of the liver in CMV/Cux-1 transgenic and non-transgenic mice 8, 10, and 14 months after birth. The total number of animals is listed in parentheses.