Table 4. Concentrations of sphingolipids in amniotic fluid.
| Group I—Down Syndrome Pregnancies (n = 10) | Group II—Pregnancies without Down Syndrome (n = 14) | P-value | |
|---|---|---|---|
| Sphingolipids concentration(ng/100μl) Mean ± SEM | Group I- Group II | ||
| Sph | 0.1687 ± 0.0415 | 0.1926 ± 0.0263 | 0.5995 |
| SPA | 0.2609 ± 0.1535 | 0.0836 ± 0.011 | 0.5571 |
| S1P | 0.1246 ± 0.044 | 0.1776 ± 0.0782 | 0.7897 |
| C14-Cer | 0.3041 ± 0.0358 | 0.4096 ± 0.0384 | 0.0734 |
| C16-Cer | 7.9872 ± 1.1811 | 15.381 ± 1.8053 | 0.0067* |
| C18:1-Cer | 0.0106 ± 0.0012 | 0.0199 ± 0.0017 | 0.0006* |
| C18-Cer | 0.3282 ± 0.0385 | 0.7078 ± 0.0564 | 0.0001* |
| C20-Cer | 2.7242 ± 0.3654 | 6.5533 ± 0.6422 | 0.0002* |
| C22-Cer | 7.0884 ± 1.0827 | 14.287 ± 2.49 | 0.0020** |
| C24:1-Cer | 13.204 ± 1.8057 | 28.280 ± 3.9798 | 0.0006** |
| C24-Cer | 15.850 ± 5.7077 | 25.697 ± 6.7947 | 0.0158** |
* statistically significant value of less than 0.05 for Student’s T-test
** statistically significant value of less than 0.05 for Mann Whitney Wilcoxon’s test