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. 2015 May 22;10(5):e0128006. doi: 10.1371/journal.pone.0128006

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© 2015 Li et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 5 — A-H: Whole mount in situ hybridization of hind limb buds showing the expression of Shh targeted genes. The expressions of Gli1 (A, B and arrowheads in C, D) and Ptc1 (E, F and arrowheads in G, H) were activated in the anterior limb bud mesenchyme in Sufu ^Dermo1Cre. I-P: Whole-mount in situ hybridization of limb buds showing that Gremlin expression was anteriorly expanded in both the fore- (K, L and arrowheads versus I, J) and hind limb buds (O, P and arrowheads versus M, N).