Table 1.
Femoral Structural Indices in Aged Mice Treated with NP1-MNP-PEG
| Trabecular Indices | Vehicle | NP1-MNP-PEG | % Change | P |
|---|---|---|---|---|
| TV [mm3]: | 0.7833 ± 0.0555 | 0.8576 ± 0.0676 | +9.5 | *0.0164 |
| BV [mm3] : | 0.1137 ± 0.0314 | 0.1897 ± 0.0927 | +66.8 | *0.0400 |
| BV/TV [%] : | 14.5 ± 3.9 | 22.1 ± 11.0 | +52.0 | *0.0482 |
| Tb.Th [mm] : | 0.0669 ± 0.0115 | 0.0627 ± 0.0085 | −6.3 | 0.3975 |
| Tb.N [1/mm]: | 7.79 ± 1.10 | 9.47 ± 3.15 | +21.5 | 0.2286 |
| Tb. Sp [mm]: | 0.1913 ± 0.0179 | 0.1627 ± 0.0512 | −15.0 | 0.1830 |
| TV. D [mg HA/cm3]: | 177.3 ± 50.8 | 252.1 ± 111.7 | +42.2 | 0.0946 |
| Cortical Indices | ||||
| Ct. Ar [mm3]: | 0.4534 ± 0.0216 | 0.4635 ± 0.0456 | 2.2 | 0.5481 |
| Ct. Th [mm]: | 1.51 ± 0.08 | 1.51 ± 0.08 | 0.0 | 0.9989 |
Structural indices: total volume (TV, volume of the entire region of interest), trabecular bone volume (BV, volume of the region segmented as trabecular bone), bone volume fraction (BV/TV), trabecular thickness (Tb. Th; mean thickness of trabeculae, assessed using direct 3D methods), trabecular separation (Tb. Sp; mean distance between trabeculae, assessed using direct 3D methods), trabecular number (Tb. N; Measure of the average number of trabeculae per unit length); and the cortical indices cortical area (Ct. Ar; Cortical bone area = cortical volume (Ct.V) ÷ (number of slices × slice thickness)) and cortical thickness (Ct. Th; average cortical thickness).21 N=9-11 mice/group
p<0.05. Mann Whitney.