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Markers of liver and kidney toxicology and systemic inflammation in aged mice treated for 4 months with vehicle or NP1-MNP-PEG.
| Serum Marker | Organ System | Vehicle | NP1-MNP-PEG | P |
|---|---|---|---|---|
| Creatinine [nmol] | Kidney | 5.8 ± 0.7 | 5.2 ± 1.4 | ns |
| ALT [nmol] | Liver | 0.1 ± 0.2 | 0.07 ± 0.1 | ns |
| TNFα [pg/mL] | Inflammation | 13.3 ± 0.8 | 15.8 ± 2.9 | ns |
Alanine aminotransferase (ALT). N=9-11 mice/group ± SEM, P= not significant (ns).
