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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2015 Apr 23;35(6):1498–1506. doi: 10.1161/ATVBAHA.114.305139

Figure 7. Proposed diagram of impaired insulin signaling in visceral obesity.

Figure 7

A) Under physiological conditions, insulin stimulates AKT activation which in turn inactivates FOXO-1 via phosphorylation, lifting an inhibitory effect of FOXO-1 on eNOS B) In pathological conditions, impaired insulin signaling and blunted eNOS activation promote endothelial dysfunction.