Table 1.
Regional MA1 VT, VT/fP and BPND values of [18F]-(−)-NCFHEB from baseline and blocking scans.
| Brain Region | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Condition | Thalamus | Front cortex | Occipital cortex | Temporal cortex | Hippocampus | Caudate | Putamen | Cerebellum | Brainstem |
| VT | |||||||||
| Baseline | 29 ± 4.9 | 13 ± 1.7 | 9.2 ± 1.0 | 11.1 ± 1.0 | 12 ± 1.0 | 10.5 ± 2.0 | 11.3 ± 1.6 | 6.4 ± 1.0 | 8.9 ± 0.7 |
| Nicotine blocking | 5.8 ± 0.1 | 7.8 ± 0.1 | 6.5 ± 0.1 | 7.0 ± 0.1 | 7.0 ± 0.2 | 6.5 ± 0.2 | 6.7 ± 0.1 | 6.2 ± 0.1 | 5.3 ± 0.1 |
| VT/fP | |||||||||
| Baseline | 33 ± 5.5 | 15 ± 1.9 | 10.5 ± 1.1 | 12.7 ± 1.2 | 13 ± 1.1 | 12.1 ± 2.2 | 12.9 ± 1.7 | 7.4 ± 1.1 | 10.2 ± 0.8 |
| Nicotine blocking | 6.1 ± 0.1 | 6.7 ± 0.1 | 6.1 ± 0.1 | 6.1 ± 0.1 | 6.2 ± 0.1 | 5.8 ± 0.1 | 6.2 ± 0.1 | 5.3 ± 0.1 | 4.9 ± 0.1 |
| BPND | |||||||||
| Baseline | 4.1 ± 1.5 | 1.2 ± 0.2 | 0.60 ± 0.33 | 0.91 ± 0.25 | 1.0 ± 0.30 | 0.84 ± 0.54 | 0.96 ± 0.45 | 0.10 ± 0.29 | 0.53 ± 0.25 |