Table 3.
Treatment-related grade 1–2 and grade 3–4 adverse events
| Total [n (%)] | ||
|---|---|---|
| No. of patients | N = 31 (100) | |
| CTC grade | Grade 1–2 | Grade 3–4 |
| Adverse event | ||
| Mucositisa | 18 (58) | 1 (3) |
| Fatigue | 17 (55) | |
| Hand-foot syndrome | 9 (29) | 5 (16) |
| Diarrhea | 13 (42) | 2 (6) |
| Nausea | 16 (52) | |
| Skinb | 20 (65) | 1 (3) |
| Anorexia | 8 (26) | |
| Vomiting | 12 (39) | 1 (3) |
| Neuropathy | 7 (23) | |
| Constipation | 4 (13) | |
| Ankle edema | 5 (16) | |
| Epistaxis | 4 (13) | |
| Infection | 3 (10) | |
| Hematology | ||
| Anemia | 25 (81) | 1 (3) |
| Thrombocytopenia | 14 (45) | 2 (6) |
| Neutropenia | 12 (39) | |
| Clinical chemistry | ||
| Hyperglycemiac | 13 (42) | 14 (45) |
| AP | 19 (61) | 2 (6) |
| ASAT | 11 (35) | |
| ALAT | 12 (39) | |
| Hypokalemia | 10 (32) | 5 (16) |
| Hyponatremia | 7 (23) | |
| Hypertriglyceridemia | 7 (23) | |
| GGT | 13 (42) | 9 (29) |
| Bilirubin | 4 (13) | 1 (3) |
| Hypercholesteremia | 3 (10) | |
GGT gamma-glutamyltransferase, ASAT aspartate aminotransferase, ALAT alanine aminotransferase, AP alkaline phosphatase
aMucositis including aphthous ulcers and stomatitis
bSkin toxicity includes rash, itching, color and nail changes
cNon-fasting glucose