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. 2015 Jan 24;14(3):264–283. doi: 10.1007/s12311-015-0645-0

Fig. 10.

Fig. 10

IntelliCage-based cognitive performance is entirely normal in female Munc13-3 −/− mice. IntelliCage testing in female Munc13-3 −/− and Munc13-3 +/+ mice. A Experimental design: IntelliCage with four conditioning corners (blue), four water bottles, four housing shelters (red), and food hopper (left). The cartoon illustrates the succession of the different experimental stages of the IntelliCage cognitive test battery. The blue circles indicate an example of a possible succession of conditioning corners, where a specific mouse could obtain water dependent on its performance in the previous stage of the test. The number of training days for each of the experimental phases is indicated (right). General activity and water intake measures across the 7 days of place learning: B corner visits, C nose pokes, and D bottle licks. E Target corner preference during the acquisition stage. General activity and water intake measures across the 9 days of multiple reversal learning: F corner visits, G nose pokes, and H bottle licks. I Corner preference during the multiple reversal stage. Mean ± SEM presented; respective sample sizes are indicated in the panels