Fig. 5.

Prepulse inhibition is not affected by Munc13-3 deficiency, but acoustic startle responses are significantly reduced in both male and female Munc13-3 ^−/− mice. The upper panel represents male and the lower panel female mice. A, B Prepulse inhibition of the acoustic startle reflex (PPI). C, d Startle response to a 120-dB stimulus. p values refer to t tests for independent samples. E, F Body weight at the time of PPI testing. G, H Detailed assessment of the acoustic startle reflex over a broad range of stimulus intensities. p values refer to the main effect of genotype obtained with repeated measures ANOVA. Mean ± SEM presented; respective sample sizes are indicated in the panels