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. Author manuscript; available in PMC: 2016 Apr 24.
Published in final edited form as: Biochem Biophys Res Commun. 2015 Apr 24;460(1):40–49. doi: 10.1016/j.bbrc.2015.02.110

FIGURE 1.

FIGURE 1

Cartoon view of STIM1 in an extended conformation, bridging the distance from ER to plasma membrane. For clarity, a single STIM monomer is shown, but the active extended form in cells is oligomeric. Functional regions of STIM discussed in the text are the calcium-sensing EF-SAM domain in the ER lumen, the cytoplasmic CC1 region that both stabilizes inactive STIM and transmits the activating conformational change upon ER calcium store depletion, the SOAR/CAD domain that recruits and gates ORAI channels, and the polybasic tail that interacts with plasma membrane phosphoinositides.