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. Author manuscript; available in PMC: 2016 Apr 24.
Published in final edited form as: Biochem Biophys Res Commun. 2015 Apr 24;460(1):40–49. doi: 10.1016/j.bbrc.2015.02.110

FIGURE 2.

FIGURE 2

Cartoon view of the ORAI1 channel. Only two subunits of the hexameric channel are depicted. Labelled are the pore-lining transmembrane helices (TM1), the E106 residues that form a calcium-binding site, the nonpolar region of the pore that constitutes the main barrier to ion flux, and the C- and N-terminal cytoplasmic segments that interact with STIM proteins.