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. Author manuscript; available in PMC: 2016 May 21.
Published in final edited form as: Cell. 2015 May 21;161(5):1187–1201. doi: 10.1016/j.cell.2015.04.044

Figure 6. Regulatory information preserved in gene correlations.

Figure 6

A) A strategy for inferring robust gene associations from cell-to-cell variability with weak and/or highly connected gene correlations, see also Fig. S6. B-D) Gene neighborhoods of Nanog, Sox2, and Cyclin B. Grey boxes mark validated pluripotency factors; blue boxes mark factors previously associated with a pluripotent state. E,F) Correlations of 44 cell cycle-regulated transcripts in a somatic cell line (K562) and in mouse ES cells shows a loss of cell cycle dependent transcription in ES cells (gene names in Fig. S6). Genes are ordered by hierarchical clustering. Color scale applies to (E,F).