TABLE 2.
Serum DBP quintile |
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Characteristics | 1 (<3670.4 nmol/L) | 2 (≥3670.4 to <4818.58 nmol/L) | 3 (≥4818.58 to <5804.71 nmol/L) | 4 (≥5804.71 to <7149.43 nmol/L) | 5 (≥7149.43 nmol/L) | P2 |
Age, y | 64.77 ± 0.443 | 64.46 ± 0.50 | 64.43 ± 0.51 | 64.90 ± 0.44 | 64.54 ± 0.47 | 0.94 |
Male sex, % | 69.49 | 58.26 | 72.50 | 60.68 | 49.57 | 0.008 |
Serum DBP, nmol/L | 2868.72 ± 54.70 | 4305.28 ± 33.00 | 5328.67 ± 27.51 | 6435.29 ± 35.71 | 9398.64 ± 181.30 | <0.0001 |
Serum 25(OH)D, nmol/L | 60.87 ± 2.31 | 60.70 ± 1.96 | 64.56 ± 2.20 | 66.15 ± 1.79 | 64.48 ± 1.99 | 0.23 |
Season of blood draw: sunny season,4 % | 47.46 | 41.74 | 39.17 | 50.43 | 49.57 | 0.38 |
Residential sun exposure at study entry5 | <0.0001 | |||||
Low sun | 49.15 | 49.57 | 36.67 | 55.56 | 41.88 | |
Moderate sun | 30.51 | 45.22 | 56.67 | 39.32 | 51.28 | |
High sun | 20.34 | 5.22 | 6.67 | 5.13 | 6.84 | |
Race, n (%) | <0.00016 | |||||
White, non-Hispanic | 71.19 | 93.04 | 93.33 | 96.58 | 96.58 | |
Black, non-Hispanic | 10.17 | 2.16 | 0.00 | 1.71 | 0.85 | |
Hispanic | 2.54 | 0.87 | 2.50 | 0.00 | 0.85 | |
Asian/Pacific Islander | 16.10 | 3.48 | 4.17 | 1.71 | 1.71 | |
Height, cm | ||||||
Male | 177.52 ± 0.92 | 177.69 ± 0.72 | 177.48 ± 0.71 | 179.37 ± 0.67 | 177.71 ± 0.85 | 0.39 |
Female | 161.71 ± 1.55 | 163.46 ± 0.89 | 161.02 ± 1.00 | 162.45 ± 0.90 | 162.22 ± 0.69 | 0.54 |
BMI, kg/m2 | 26.88 ± 0.42 | 26.86 ± 0.39 | 27.31 ± 0.43 | 26.87 ± 0.36 | 26.51 ± 0.39 | 0.73 |
WHO cutoffs, % | 0.85 | |||||
<25.0 kg/m2 | 35.59 | 32.17 | 32.50 | 34.19 | 42.74 | |
≥25.0 and <30.0 kg/m2 | 44.92 | 47.83 | 45.83 | 46.15 | 41.03 | |
≥30.0 kg/m2 | 19.49 | 20.00 | 21.67 | 19.66 | 16.24 | |
Smoking status, % | 0.93 | |||||
Never | 51.69 | 51.30 | 49.17 | 52.99 | 43.59 | |
Former | ||||||
Quit ≥15 y | 27.97 | 30.43 | 25.85 | 26.50 | 34.19 | |
Quit <15 y | 12.71 | 11.30 | 18.33 | 13.68 | 14.53 | |
Current | 7.63 | 6.96 | 6.67 | 6.84 | 7.69 | |
History of diabetes mellitus, % | 11.86 | 10.43 | 7.50 | 6.84 | 5.13 | 0.03 |
Family history of pancreatic cancer, % | 4.24 | 3.48 | 0.00 | 2.56 | 3.42 | 0.59 |
Dietary intake per day7 | ||||||
Red meat, g | 85.18 ± 7.16 | 84.77 ± 5.05 | 73.60 ± 5.28 | 80.15 ± 4.45 | 78.00 ± 4.32 | 0.51 |
Alcohol, g | 12.55 ± 2.62 | 8.55 ± 1.48 | 15.06 ± 3.53 | 8.96 ± 1.48 | 10.07 ± 2.10 | 0.26 |
Nutrients | ||||||
Vitamin D, μg | ||||||
Food | 5.32 ± 0.25 | 5.72 ± 0.32 | 5.87 ± 0.30 | 6.19 ± 0.27 | 5.73 ± 0.31 | 0.34 |
Supplemental | 5.87 ± 0.78 | 7.41 ± 0.92 | 5.17 ± 0.63 | 7.00 ± 0.91 | 7.89 ± 1.00 | 0.14 |
Total | 11.23 ± 0.85 | 13.12 ± 0.99 | 11.08 ± 0.73 | 13.18 ± 0.91 | 12.59 ± 1.06 | 0.15 |
Calcium, mg | ||||||
Food | 946.36 ± 32.50 | 1034.20 ± 38.45 | 1012.70 ± 38.93 | 1047.54 ± 34.78 | 1033.36 ± 37.40 | 0.31 |
Supplemental | 212.98 ± 31.89 | 225.85 ± 33.76 | 214.42 ± 32.77 | 264.70 ± 33.21 | 338.37 ± 41.24 | 0.05 |
Total | 1164.51 ± 46.80 | 1259.79 ± 52.68 | 1233.18 ± 52.37 | 1312.20 ± 48.35 | 1366.15 ± 54.92 | 0.06 |
Total vitamin A,8 RE | 1888.64 ± 86.66 | 1761.83 ± 63.97 | 1744.32 ± 60.49 | 1806.84 ± 75.65 | 1768.45 ± 58.78 | 0.61 |
Vigorous physical activity of ≥4 h/wk, %7 | 27.12 | 19.13 | 30.00 | 29.91 | 22.22 | 0.95 |
DBP, vitamin D–binding protein; RE, retinol equivalents; 25(OH)D, 25-hydroxyvitamin D.
Calculated using generalized linear models for continuous variables and chi-square test for categorical variables, unless otherwise specified
Mean ± SD (all such values).
Sunny season was defined as June–October; low sun season was defined as November–May.
Residential regions based on ranges of UV radiation levels obtained from annual Robertson-Berger (R-B) meters in states in which screening centers are located: low sun (≤105 R-B meters; Detroit, MI; Minneapolis, MN; and Marshfield, WI), moderate sun (113–134 R-B meters; Pittsburgh, PA; St. Louis, MO; Denver, CO; Washington, DC; and Salt Lake City, UT), and high sun (≥154 R-B meters; Birmingham, AL, and Honolulu, HI) (13).
Calculated by using Fisher’s exact test due to small cell sizes for non-Hispanic black, Hispanic, and Asian/Pacific Islander study participants.
Based on data for n = 554 controls; 33 controls had missing dietary questionnaires, missing data for all the dietary variables, or missing physical activity data. All foods and nutrients were energy adjusted except for supplements and alcohol.
Total vitamin A includes vitamin A from food and supplements.