TABLE 4.
Crude and multivariable-adjusted ORs (95% CIs) of baseline serum 25(OH)D concentrations and pancreatic cancer based on clinical cutoffs in 295 cases and 587 controls1
| Serum 25(OH)D |
||||||
| <25.0 nmol/L | ≥25.0 to <37.5 nmol/L | ≥37.5 to <50.0 nmol/L | ≥50.0 to <75.0 nmol/L | ≥75.0 to <100.0 nmol/L | ≥100.0 nmol/L | |
| Cases/controls, n/n | 21/22 | 32/45 | 50/99 | 105/254 | 67/143 | 20/24 |
| Crude OR (95% CI) | 3.00 (1.13, 7.99)* | 1.68 (0.89, 3.19) | 1.21 (0.73, 2.01) | 1.00 (reference) | 1.43 (0.92, 2.24) | 3.10 (1.23, 7.85)* |
| Multivariable-adjusted OR (95% CI) | 2.50 (0.92, 6.81) | 1.42 (0.74, 2.76) | 1.25 (0.74, 2.11) | 1.00 (reference) | 1.42 (0.90, 2.25) | 3.23 (1.24, 8.44)*2 |
| Lag analysis for cases diagnosed >5 y after baseline | ||||||
| Cases/controls(n = 199/404), n/n | 19/16 | 19/31 | 36/83 | 70/176 | 58/104 | 12/18 |
| Crude OR (95% CI) | 3.75 (1.28, 10.96)* | 1.29 (0.59, 2.84) | 1.11 (0.62, 1.99) | 1.00 (reference) | 1.87 (1.11, 3.15)* | 2.53 (0.78, 8.20) |
| Multivariable-adjusted OR (95% CI) | 3.18 (1.06, 9.54)* | 1.05 (0.47, 2.37) | 1.15 (0.64, 2.09) | 1.00 (reference) | 1.85 (1.09, 3.15)*2 | 2.57 (0.77, 8.60) |
A chi-square test of the association between 25(OH)D and case status produced a P value of 0.03. The crude model was calculated by using conditional logistic regression and conditioned on matched variables (age, race-ethnicity, sex, and date of blood draw based on 2-mo blocks). The multivariable model was calculated by using conditional logistic regression, conditioned on matched variables (age, race-ethnicity, sex, and date of blood draw based on 2-mo blocks) and adjusted for smoking status (never; former, ≥15 y; former, <15 y; current) and self-reported diabetes (yes or no). *Significant. 25(OH)D, 25-hydroxyvitamin D.
Significant at the Bonferroni-corrected P value, 0.05/2 = 0.025.