TABLE 5.
ORs (95% CIs) for the joint effect of serum DBP and serum 25(OH)D and risk of pancreatic cancer in 295 cases and 587 controls1
| Serum 25(OH)D |
|||||
| <50.0 nmol/L | ≥50.0 to <75.0 nmol/L | ≥75.0 nmol/L | P-trend | P-interaction2 | |
| Multivariable-adjusted OR3 (95% CI) (n = 295/587) | 0.12 | ||||
| Cases/controls, n/n | 62/96 | 45/125 | 39/72 | ||
| DBP less than median | 2.05 (1.06, 3.98)* | 1.00 (reference) | 1.60 (0.82, 3.11) | 0.63 | |
| Cases/controls, n/n | 41/70 | 60/129 | 48/95 | ||
| DBP of median or greater | 1.27 (0.65, 2.47) | 1.31 (0.71, 2.39) | 2.08 (1.08, 4.00)* | 0.11 | |
| Lag analysis for cases diagnosed >5 y after baseline3 (n = 214/428) | 0.04 | ||||
| Cases/controls, n/n | 46/71 | 26/84 | 32/64 | ||
| DBP less than median | 2.28 (1.04, 5.00)* | 1.00 (reference) | 1.88 (0.86, 4.10) | 0.87 | |
| Cases/controls, n/n | 28/59 | 44/92 | 38/58 | ||
| DBP of median or greater | 1.17 (0.54, 2.55) | 1.43 (0.69, 2.96) | 3.19 (1.44, 7.09)*4 | 0.02* | |
A chi-square test of the association between the joint variable [DBP and 25(OH)D combined status] and case status produced a P value of 0.21. Multivariable and lag analysis ORs and 95% CIs were calculated by using conditional logistic regression, conditioned on matched variables (age, race-ethnicity, sex, month of blood draw) and adjusted for smoking status (never; former, ≥15 y; former, <15 y; current) and self-reported diabetes (yes or no). *Significant. DBP, vitamin D–binding protein; 25(OH)D, 25-hydroxyvitamin D.
Based on clinically relevant 25(OH)D cutoffs and median split DBP.
The median DBP is 5358.19 nmol/L.
Significant at the Bonferroni-corrected P value, 0.05/2 = 0.025.