TABLE 5.

RRs (95% CI) of total, ischemic, and hemorrhagic strokes by quintiles of combined diet scores for magnesium, potassium, and calcium intakes in 86,149 women in the NHS I and 94,715 women in the NHS II¹

	Quintile 1	Quintile 2	Quintile 3	Quintile 4	Quintile 5	P-linear trend
Median combined diet score
NHS I	3	6	9	11	14	—
NHS II	3	6	9	11	14	—
Total stroke
Age-adjusted model
NHS I	1.0 (reference)	0.81 (0.71, 0.91)	0.76 (0.67, 0.86)	0.87 (0.67, 0.87)	0.72 (0.64, 0.82)	<0.001
NHS II	1.0 (reference)	0.75 (0.56, 0.99)	0.82 (0.61, 1.09)	0.75 (0.57, 0.98)	0.71 (0.53, 0.94)	0.05
Pooled	1.0 (reference)	0.80 (0.71, 0.89)	0.77 (0.69, 0.87)	0.77 (0.69, 0.86)	0.72 (0.65, 0.81)	<0.001
Multivariate model
NHS I	1.0 (reference)	0.85 (0.75, 0.96)	0.83 (0.73, 0.94)	0.86 (0.76, 0.96)	0.81 (0.72, 0.92)	0.007
NHS II	1.0 (reference)	0.78 (0.59, 1.04)	0.88 (0.66, 1.18)	0.83 (0.63, 1.09)	0.78 (0.58, 1.05)	0.25
Pooled	1.0 (reference)	0.84 (0.75, 0.94)	0.84 (0.74, 0.94)	0.85 (0.76, 0.95)	0.81 (0.72, 0.91)	0.003
Ischemic stroke
Age-adjusted model
NHS I	1.0 (reference)	0.81 (0.68, 0.96)	0.81 (0.67, 0.96)	0.80 (0.68, 0.95)	0.74 (0.62, 0.87)	0.002
NHS II	1.0 (reference)	0.74 (0.46, 1.19)	0.75 (0.46, 1.24)	0.69 (0.44, 1.08)	0.66 (0.41, 1.08)	0.12
Pooled	1.0 (reference)	0.80 (0.68, 0.94)	0.80 (0.68, 0.95)	0.79 (0.69, 0.92)	0.73 (0.62, 0.85)	<0.001
Multivariate model
NHS I	1.0 (reference)	0.83 (0.70, 0.99)	0.83 (0.69, 0.99)	0.85 (0.72, 1.00)	0.78 (0.66, 0.93)	0.03
NHS II	1.0 (reference)	0.79 (0.49, 1.28)	0.82 (0.49, 1.36)	0.77 (0.48, 1.25)	0.75 (0.45, 1.25)	0.34
Pooled	1.0 (reference)	0.83 (0.71, 0.97)	0.83 (0.70, 0.98)	0.84 (0.72, 0.98)	0.78 (0.66, 0.92)	0.01
Hemorrhagic stroke
Age-adjusted model
NHS I	1.0 (reference)	0.76 (0.57, 1.00)	0.71 (0.53, 0.96)	0.69 (0.53, 0.91)	0.73 (0.55, 0.96)	0.04
NHS II	1.0 (reference)	0.90 (0.44, 1.81)	1.03 (0.50, 2.11)	0.92 (0.47, 1.81)	0.74 (0.36, 1.56)	0.50
Pooled	1.0 (reference)	0.78 (0.60, 1.01)	0.75 (0.57, 0.99)	0.72 (0.56, 0.93)	0.73 (0.56, 0.95)	0.03
Multivariate model
NHS I	1.0 (reference)	0.93 (0.71, 1.22)	0.69 (0.51, 0.94)	0.86 (0.64, 1.14)	0.69 (0.52, 0.91)	0.25
NHS II	1.0 (reference)	0.83 (0.41, 1.68)	0.95 (0.46, 1.97)	0.83 (0.41, 1.65)	0.66 (0.31, 1.39)	0.35
Pooled	1.0 (reference)	0.81 (0.62, 1.05)	0.61 (0.61, 1.06)	0.77 (0.60, 1.00)	0.80 (0.61, 1.04)	0.15

¹Cox proportional hazards models were used to estimate RRs and 95% CIs. The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m²; <25, 25 to <30, or ≥30), parental history of heart disease (aged ≤60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ≥15 g/d), physical activity (<3, 3 to <9, 9 to<18, 18 to <27, or ≥27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ≥2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses’ Health Study.