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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Free Radic Biol Med. 2015 Feb 4;83:101–114. doi: 10.1016/j.freeradbiomed.2015.01.029

Figure 2.

Figure 2

Effect of NONO-aspirin prodrugs or aspirin in nude mice implanted with 7.5 × 105 MDA-MB-231 cells stably transfected with GFP. The cells were allowed to grow for 14 d, and the animals (40) were randomly divided into four groups (control, aspirin, IPA/NO-aspirin or DEA/NO-aspirin). Treated groups were injected daily with equimolar doses of DEA/NO-aspirin or IPA/NO-aspirin (16 mg/kg) or aspirin (9 mg/kg) or with DMSO for the next five weeks. Tumor size was then measured using in vivo fluorescent imaging for quantification of the GFP tag: A) qualitative image of individual animals, B) quantitative analysis of fluorescence intensity at the primary tumor site (n = 5), C) qualitative image of individual brains, D) quantitative analysis of fluorescence intensity due to metastasis to the brain (n = 7). *p < 0.001 vs. control.