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. Author manuscript; available in PMC: 2016 Jun 1.

Published in final edited form as: Free Radic Biol Med. 2015 Feb 4;83:101–114. doi: 10.1016/j.freeradbiomed.2015.01.029

Effect of the NONO-aspirin prodrugs on DNA damage in MDA-MB-231 cells as determined using the Comet assay after 8 h at 37 °C: A) 50 μM IPA/NO-aspirin, B) 75 μM DEA/NO-aspirin, C) 0.1% DMSO or D) 100 μM H₂O₂. Tail length is quantified in E (mean ± SEM, n ≥ 150).

Effect of the NONO-aspirin prodrugs on DNA damage in MDA-MB-231 cells as determined using the Comet assay after 8 h at 37 °C: A) 50 μM IPA/NO-aspirin, B) 75 μM DEA/NO-aspirin, C) 0.1% DMSO or D) 100 μM H₂O₂. Tail length is quantified in E (mean ± SEM, n ≥ 150).