Fig 3.
Contractile profile of isolated right-ventricular papillary muscles indicates rapid contraction and relaxation in T4-treated mice. Representative bar graphs show (A) mean isometric developed force (Fdev), (B) their corresponding time to peak (TTP), and (C) 50% relaxation time (RT50) at 4 Hz stimulation frequency and 2 mmol/L Ca2+. Control, n=12; T4, n=11; allopurinol, n=10; apocynin, n=10; L-NIO, n=9; MitoTEMPO, n=9. *Significant change compared with T4 group (one-way ANOVA followed by Dunnett multiple comparisons post hoc test, comparing all groups to T4).