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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Free Radic Biol Med. 2015 Feb 17;83:139–148. doi: 10.1016/j.freeradbiomed.2015.01.035

Figure 6. Reduced caspase-1 activation in MKK3−/− BMDMs after LPS + ATP injury.

Figure 6

BMDMs were treated with LPS and ATP to check the activation of caspase-1. Caspase-1 activity was significantly increased in WT after LPS (0.1 μg/ml) + ATP (5uM) treatment but MKK3−/− BMDMs did not show any significant change compared to control (A). The levels of cleaved caspase-1 were lower in MKK3−/− BMDMs compared to WT after LPS + ATP treatment (B). * represents significance between control and LPS treated within same genotype and # represents significance between the genotypes within LPS treatment groups, and ** or ## represents significance at p<0.01. Data is representative of 3 experiments done in at least triplicates.