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Spectroscopic insights into basal activity of unliganded β2AR.
(A) DEER derived distance distributions for unliganded β2AR with the carazolol-bound distribution superimposed. See Figure S3 for DEER data with ICI-118,551.
(B)19F-NMR spectra of unliganded β2AR with CPMG relaxation dispersions shown in the inset. The simulated lineshape for unliganded β2AR is shown in grey.
(C) 19F-NMR simulated S1 and S2 states for unliganded β2AR compared to carazolol-bound β2AR.
