Table 1.
Weighted study population demographic characteristics and plasma angiogenic biomarker distributions (median, [25th, 75th percentiles]) within demographic groups (N=457 subjects; 1611 observations).
| Demographic characteristic (weighted percent of total population) | sFlt-1 (ng/mL) | PlGF (pg/mL) | |
|---|---|---|---|
| Race/ethnicity | White (58) | 6.4 (3.9, 9.6) | 142 (34.5, 410) |
| African-American (16) | 7.0 (4.4, 11.0) | 198 (57.1, 456)a | |
| Other (26) | 6.7 (4.3, 10.4) | 169 (49.7, 430) | |
| Education | High school (14) | 6.7 (4.3, 9.7) | 181 (52.1, 478) |
| Technical school (16) | 7.0 (4.1, 11.4) | 171 (44.3, 473) | |
| Junior college or some college (30) | 5.5 (3.8, 9.7) | 136 (36.7, 354) | |
| College graduate (40) | 6.9 (4.5, 9.8) | 153 (41.3, 420) | |
| Health insurance | Private insurance/HMO/Self-pay (81) | 6.5 (4.1, 9.8) | 148 (37.3, 404) |
| Medicaid/SSI/MassHealth (19) | 6.8 (4.3, 11.3) | 209 (52.9, 486) | |
| BMI at initial visit | Less than 25 kg/m2 (54) | 6.7 (4.3, 10.3) | 159 (41.2, 452) |
| 25 to less than 30 kg/m2 (26) | 7.1 (4.4, 10.4) | 163 (46.5, 415) | |
| Greater than 30 kg/m2 (20) | 5.1 (3.3, 8.1) | 124 (34.3, 325) | |
| Tobacco use | Smoked during pregnancy (6) | 5.7 (3.5, 8.2) | 173 (40.0, 371) |
| No smoking during pregnancy (94) | 6.6 (4.2, 10.0) | 153 (40.9, 420) | |
| Alcohol use | Alcohol use during pregnancy (5) | 8.1 (4.2, 10.6) | 158 (39.3, 427) |
| No alcohol use during pregnancy (95) | 6.5 (4.1, 9.9) | 153 (40.9, 419) | |
| Parity | Nulliparous (45) | 7.3 (4.4, 12.1) | 141 (39.2, 380) |
| Non-nulliparous (55) | 6.0 (3.9, 8.7) | 171 (41.2, 455) | |
| Fetal gender | Male (44) | 6.8 (4.3, 11.1) | 151 (41.2, 396) |
| Female (56) | 6.2 (3.9, 9.6) | 162 (40.1, 438) | |
| Case status | Preterm (11) | 5.5 (3.8, 9.2) | 120 (30.8, 296) |
| Term (89) | 6.6 (4.1, 10.0) | 159 (41.2, 429) | |
a
Bolding indicates significant difference (p<0.05) in angiogenic biomarker concentrations in demographic group compared to reference (first category listed). Results drawn from linear mixed models adjusting for subject-specific random intercepts and slopes. Abbreviations: sFlt-1, soluble fms-like tyrosine kinase-1; PlGF, placental growth factor; HMO, health maintenance organization; SSI, supplemental security income.