Table 1:
Data sources and evidence level of recommendations with citation in the National Tuberculosis Guideline
| No | Recommendation Title | Study cited in national guideline | Systematic review found in-search | Evidence level of systematic review | ||
|---|---|---|---|---|---|---|
| Type of study | Location of study | Evidence level † | ||||
| 1 | DOTS strategy shall be used for treatment of patients | Systematic review | International | ++1 | √ | ++1 |
| 2 | Sputum test shall be sued for diagnosis (first method of diagnosis) | Diagnostic tests | International | ++3 | ||
| 3 | Sputum culture has more sensitivity compared to direct sputum test | Narrative review | International | ++2 | ||
| 4 | prophylaxis of in contact cases shall be done by Isoniazid | Systematic review | International | ++1 | √ | ++1 |
| 5 | Treatment period of new cases shall be at least 6 months | RCT (10) | International | +1 | √ (11) | ++1 |
| 6 | In the first treatment category, attack phase is 2 months and maintenance phase is 4 months | RCT (10) | International | +1 | √ (11) | ++1 |
| 7 | Once vaccination of BCG is enough during life | Case-control (12) | International | +2 | √ (13) | ++1 |
| 8 | Children undue 6 with 3 criteria out of 5 TB diagnostic criteria (history of contact, positive PPD, suspected pulmonary radiography, positive sputum or gastric juice, TB clinical symptoms) should receive TB perfect treatment | Narrative review | International | ++2 | ||
| 9 | Prophylaxis of children under 6 in contact is required in case of TB rejection | Narrative review | International | ++2 | ||
| 10 | In individual with HIV-positive and PPD positive (stiffness diameter equal to 5 mg or greater) provided rejection of active TB, initiation of preventive treatment is necessary. | Systematic review | International | +++1 | √ | +++1 |
| 11 | 9 month Isoniazid for prophylaxis in HIV-positive patients treated with antiretroviral | RCT (14) | International | +1 | √ (15) | +++1 |
| 12 | Preventive therapy in HIV-positive patients who are treated with antiretroviral drugs is Isoniazid and Rifampin with usual dose for three months | Systematic review | International | ++1 | √ | ++1 |
| 13 | In HIV-positive patients treated with anti-TB drugs because of the high prevalence of neuropathy in these patients, 50 mg of pyridoxine should be given daily with Isoniazid. | Narrative review | International | ++2 | ||
| 14 | Rifampin interferes with the effects of contraceptives and may lead to unwanted pregnancy | Narrative review | International | ++2 | ||
| 15 | Use of Streptomycin is contraindicated in pregnancy | Narrative review | International | ++2 | ||
† Definition of items in this column is given in table 3.