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. Author manuscript; available in PMC: 2016 Jul 15.
Published in final edited form as: Behav Brain Res. 2015 Apr 6;288:26–32. doi: 10.1016/j.bbr.2015.03.066

Table 1.

Outline of experimental groups for the nicotine + ethanol sensitization studies

Baseline Acquisition Ethanol Challenge
Treatment Groups Day 3–12 (Day 13) Day 1–2 Day 3 Day 4–5 Day 6 Day 7–8 Day 9 Day 10–11 Day 12 Day 13
1 g/kg ethanol groups
SAL (E1) SAL SAL SAL SAL SAL SAL SAL SAL (E1)
N1 (E1) SAL N1 N1 N1 N1 N1 N1 N1 (E1)
N2 (E1) SAL N2 N2 N2 N2 N2 N2 N2 (E1)
E1 (E1) SAL E1 E1 E1 E1 E1 E1 E1 (E1)
N1+E1 (E1) SAL N1+E1 N1+E1 N1+E1 N1+E1 N1+E1 N1+E1 N1+E1 (E1)
N2+E1 (E1) SAL N2+E1 N2+E1 N2+E1 N2+E1 N2+E1 N2+E1 N2+E1 (E1)
2 g/kg ethanol groups
SAL (E2) SAL SAL SAL SAL SAL SAL SAL SAL (E2)
N1 (E2) SAL N1 N1 N1 N1 N1 N1 N1 (E2)
N2 (E2) SAL N2 N2 N2 N2 N2 N2 N2 (E2)
E2 (E2) SAL E2 E2 E2 E2 E2 E2 E2 (E2)
N1+E2 (E2) SAL N1+E2 N1+E2 N1+E2 N1+E2 N1+E2 N1+E2 N1+E2 (E2)
N2+E2 (E2) SAL N2+E2 N2+E2 N2+E2 N2+E2 N2+E2 N2+E2 N2+E2 (E2)
Activity test Yes Yes No Yes No Yes No Yes Yes & Blood

“E1” or “E2” = 1 or 2 g/kg ethanol. “SAL”= 0.9% Saline. “N1” or “N2” = 1 or 2 mg/kg of nicotine tartrate. Yes = activity test occurs. No = no activity test.