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Transcripts encoding SERT are downregulated in the ileum and colon of TPH1/2dKO mice. Real-time PCR was used to quantify to abundance of transcripts encoding SERT. For each sample, the abundance of transcripts encoding SERT was normalized to that of GAPDH. Data are expressed as the ratio of transcripts encoding SERT to those of GAPDH. SERT expression in both ileum and colon of TPH1/2dKO animals was significantly lower than that in their wild-type littermates.
