TABLE 1.

Fluxes and amino acid concentrations of BL6 and ICR mice fed arginine-sufficient (8-g arginine/kg diet) and arginine-free diets¹

	BL6		ICR
	Arg−	Arg+	Arg−	Arg+	Gen	TRT	Gen × TRT
Fluxes, μmol ⋅ kg−1 ⋅ h−1
RaPhe2	330 ± 10	336 ± 16	326 ± 14	320 ± 17	0.52	0.99	0.71
RaTyr2	298 ± 10	294 ± 14	276 ± 10	303 ± 12	0.62	0.43	0.29
RcPhe→Tyr2	58 ± 5	55 ± 5	47 ± 3	68 ± 11	0.86	0.17	0.09
Plasma concentrations, μmol/L
Citrulline	124 ± 5	126 ± 11	170 ± 5	146 ± 7*	0.001	0.23	0.16
Arginine	124 ± 8	165 ± 18	150 ± 16	147 ± 10	0.83	0.29	0.23
Ornithine	103 ± 11	109 ± 12	162 ± 4	131 ± 5*	0.002	0.31	0.14

¹Values are means ± SEMs, n = 10. *Different from corresponding Arg−, P < 0.05. BL6, C57BL/6; Gen, genotype; ICR, Institute of Cancer Research; TRT, treatment.

²RaPhe, RaTyr, and RcPhe→Tyr: rate of appearance of phenylalanine and tyrosine, and rate of conversion of phenylalanine into tyrosine.