TABLE 2.
Dietary fat intakes modulated the genotype effect of the LIPC rs2070895 variant on the changes in lipids in response to the dietary fat intervention at 2 y1
| Low-fat diet | High-fat diet | P-interaction | |
| ΔTotal cholesterol,2 mg/dL | |||
| AA | 20 (−24.7 ± 8.2) | 20 (7.4 ± 9.5) | |
| AG | 101 (−15.0 ± 5.2) | 98 (1.3 ± 7.8) | |
| GG | 155 (−11.2 ± 5.2) | 149 (−6.3 ± 7.6) | |
| P-trend3 | 0.07 | 0.008 | 0.0008 |
| ΔLDL cholesterol,2 mg/dL | |||
| AA | 20 (−21.8 ± 6.8) | 20 (10.7 ± 8.1) | |
| AG | 101 (−11.2 ± 4.3) | 98 (6.3 ± 6.7) | |
| GG | 155 (−8.7 ± 4.3) | 149 (2.1 ± 6.5) | |
| P-trend3 | 0.06 | 0.07 | 0.004 |
| ΔHDL cholesterol,2 mg/dL | |||
| AA | 20 (2.73 ± 1.85) | 20 (5.67 ± 2.42) | |
| AG | 101 (3.32 ± 1.16) | 98 (9.02 ± 1.99) | |
| GG | 155 (4.81 ± 1.16) | 149 (7.09 ± 1.95) | |
| P-trend3 | 0.048 | 0.54 | 0.03 |
1
Values are n (means ± SEs). LIPC, hepatic lipase gene.
2
The Δ variables indicate the change of respective outcomes.
3
P-trend was for general linear regression in which an additive genetic model was analyzed for the rs2070895 variant. The adjustment was including age, sex, ethnicity, baseline BMI, weight loss, and baseline values for respective outcomes.