Table 1.
Baseline patient characteristics stratified by virological and immunological failure
| Characteristic | Total (n=2172) | Virological success | Virological failure | p Value | Immunological success | Immunological failure | p Value |
|---|---|---|---|---|---|---|---|
| Median age (IQR), years | 33 (28–40) | 33 (28–40) | 33 (29–40) | 0.667 | 33 (28–40) | 34 (29–42) | 0.013 |
| Male, n (%) | 1699 (78.2) | 1474 (78.4) | 225 (77.1) | 0.594 | 1392 (78.6) | 307 (76.8) | 0.422 |
| Married, n (%) | 1070 (49.3) | 913 (48.6) | 157 (53.8) | 0.002 | 853 (48.1) | 217 (54.3) | 0.031 |
| BMI ≥18.5 (kg/m2), n (%) | 1481 (82.8) | 1335 (82.9) | 146 (82.0) | 0.754 | 1258 (83.6) | 223 (78.3) | 0.032 |
| Education: middle school, n (%) | 1362 (62.7) | 1174 (62.5) | 188 (64.4) | 0.558 | 1107 (62.8) | 255 (63.8) | 0.647 |
| Occupation: commercial service, n (%) | 525 (24.8) | 452 (24.6) | 73 (25.9 | 0.657 | 450 (26.0) | 75 (19.4) | 0.013 |
| Infection route: heterosexual, n (%) | 1125 (51.8) | 978 (52.1) | 147 (50.3) | 0.615 | 906 (51.1) | 219 (54.8) | 0.203 |
| Median baseline CD4 cell count (IQR), cells/mm3 | 168 (71–242) | 169 (71–243) | 167 (70–242) | 0.542 | 172 (74–245) | 135 (31–226.5) | <0.001 |
| CD4 cell count <50 cells/mm3, n (%) | 423 (19.5) | 362 (19.3) | 61 (20.9) | 0.525 | 287 (16.2) | 136 (34.0) | <0.001 |
| Median baseline viral load (IQR), copies/mL | 162 000 (42 200–467 750) | 150 500 (39 975–444 000) | 252 000 (101 000–779 750) | <0.001 | 157 000 (43 700–455 000) | 175 000 (35 600–591 000) | 0.278 |
| Viral load ≥100 000 copies/mL, n (%) | 1184 (62.5) | 1032 (61.0) | 153 (75.4) | <0.001 | 978 (62.1) | 206 (64.6) | 0.447 |
| Median haemoglobin level (IQR), g/L | 140 (122–151) | 141 (122–151) | 136 (122–150) | 0.414 | 141 (124–151) | 136 (118–149) | 0.013 |
| Median ALT level (IQR), U/L | 22 (15–37) | 22 (15–37) | 25 (16–39) | 0.104 | 22 (15–36) | 22 (14–38) | 0.664 |
| Median AST level (IQR), U/L | 24 (20–32) | 24 (19–32) | 26 (20–35) | 0.177 | 24 (19–32) | 24 (20–34) | 0.520 |
| Baseline WHO stage IV, n (%) | 726 (33.4) | 579 (30.8) | 147 (50.3) | <0.001 | 553 (31.2) | 173 (43.3) | <0.001 |
| Baseline AIDS status, n (%) | 1556 (73.4) | 1347 (73.3) | 209 (74.4) | 0.380 | 1273 (73.5) | 283 (73.1) | 0.466 |
| HBV positive, n (%) | 198 (13.2) | 183 (13.6) | 15 (9.9) | 0.255 | 171 (13.4) | 27 (12.2) | 0.747 |
| HCV positive, n (%) | 72 (4.8) | 70 (5.2) | 2 (1.3) | 0.028 | 52 (4.1) | 20 (8.9) | 0.004 |
| Tuberculosis, n (%) | 86 (4.0) | 75 (4.0) | 11 (3.9) | 0.730 | 60 (3.4) | 26 (6.7) | 0.003 |
ALT, alanine aminotransferase; AST, aspartate transaminase; HBV, hepatitis B virus; HCV, hepatitis C virus.