Figure 2.
The schematic summarization for the signaling mechanisms of the antifibrotic effects of H2S. (a) H2S inhibits LPS-induced inflammation through the Toll-like receptor-NF κB signal transduction. (b) H2S ablates the activation of TGF-β1 and MAPK kinases pathway. (c) H2S regulates redox production by inhibiting the expression/activity of NOX4 in addition to direct reaction with some reactive oxygen species (ROS). Lastly, H2S is able to modulate cellular metabolism and homeostasis by activating AMPK and sirtuin 1.