Table 3.
Frequency of AQP4-Ab in ON among different countries.
| Ethnicity | Age | M : F | AQP4-Ab seropositive | |||
|---|---|---|---|---|---|---|
| Total (%) | RON (%) | ION (%) | ||||
| Our study | China, South | 37.3 | 7 : 29 | 19/36 (52.8) | 8/13 (69.2) | 10/23 (43.5) |
| Long et al. [10] | China, South | 31.25 | 4 : 9 | 4/13 (30.8) | 3/8 (38) | 1/5 (20) |
| Chan et al. [11] | China, South | — | — | 3/23 (13) | 2/9 (33) | 1/14 (14) |
| Lai et al. [12]∗ | China, North | 31.1 | 12 : 22 | 11/34 (32.4) | 5/11 (45.5) | 6/23 (26.1) |
| Li et al. [13] | China, North | 38.89 | 55 : 135 | 13/190 (6.8) | 10/79 (12.7) | 3/114 (2.6) |
| Takagi et al. [14] | Japan | 46 | 13 : 19 | 3/32 (9.3) | — | — |
| Matiello et al. [15] | American | — | 2 : 23 | — | 5/25 (20) | — |
| Banwell et al. [5]∗∗ | #Multi | 12.6 (7.4–17.9) | 1 : 1.2 | 1/13 (7.7) | 1/5 (20) | 0/8 (0) |
| Petzold et al. [6] | UK | 29 | 3 : 6 | 4/77 (5.2) | 2/36 (6) | 2/41 (5) |
| Costa et al. [7] | Spain | 28 (13–48) | 34 : 67 | 3/101 (3.1) | — | — |
| Jarius et al. [8] | ##Multicountries | 34 | 35 : 104 | 8/139 (5.8) | 5/50 (10) | 3/89 (3.4) |
ION: isolated monophasic optic neuritis, RON: recurrent optic neuritis; ∗severe ON visual acuity of 20/200 or worse in at least 1 eye at the nadir; ∗∗pediatric cases; #serum from multiple ethnicity of White, Asian, Black, Hispanic, Mestizo, Middle Eastern, and Native Argentinean; ##serum from Austria, Denmark, France, Germany, Italy, and Turkey.