TABLE 4.
Summary of the occurrence of monkeypox-related lesions and positive immunohistochemistry results in cynomolgus macaques following challenge with monkeypox virusa
| Organ | No. of samples with positive H&E or IHC results/total no. of samples |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day 2 |
Day 4 |
Day 6 |
Day 8 |
Day 10 |
Day 12 |
|||||||
| H&E | IHC | H&E | IHC | H&E | IHC | H&E | IHC | H&E | IHC | H&E | IHC | |
| Trachea/larynx | 0/3 | 0/3 | 0/3 | 0/3 | 1/3 | 1/3 | 1/5 | 1/5 | 0/3 | 0/3 | 1/4 | 1/4 |
| Lung RU | 0/3 | 3/3 | 3/3 | 3/3 | 3/3 | 3/3 | 5/5 | 5/5 | 3/3 | 3/3 | 4/4 | 2/4 |
| Lung RM | 0/3 | 3/3 | 3/3 | 3/3 | 3/3 | 3/3 | 5/5 | 5/5 | 3/3 | 3/3 | 4/4 | 2/4 |
| Lung RL | 1/3 | 3/3 | 3/3 | 3/3 | 3/3 | 3/3 | 5/5 | 5/5 | 3/3 | 3/3 | 4/4 | 2/4 |
| Lung LU | 1/3 | 3/3 | 2/3 | 3/3 | 3/3 | 3/3 | 5/5 | 5/5 | 3/3 | 3/3 | 4/4 | 3/4 |
| Lung LL | 2/3 | 3/3 | 3/3 | 3/3 | 3/3 | 3/3 | 5/5 | 5/5 | 3/3 | 3/3 | 4/4 | 3/4 |
| Hilar LN | 0/2 | 0/2 | 1/3 | 2/3 | 3/3 | 3/3 | 4/5 | 4/5 | 1/3 | 2/3 | 2/3 | 1/4 |
| Spleen | 0/3 | 0/3 | 0/3 | 1/3 | 3/3 | 3/3 | 3/5 | 4/5 | 2/3 | 1/3 | 2/4 | 0/4 |
| Tongue | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 2/5 | 2/5 | 0/3 | 0/3 | 0/3 | 0/3 |
| Tonsil | 0/3 | 0/3 | 0/3 | 0/3 | 3/3 | 3/3 | 3/3 | 3/3 | 2/2 | 2/2 | 0/2 | 0/2 |
| Mandibular LN | 0/3 | 0/3 | 0/2 | 1/2 | 2/2 | 2/2 | 2/5 | 3/5 | 1/3 | 1/3 | 0/3 | 0/3 |
| Stomach | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 0/5 | 1/5 | 0/3 | 0/3 | 0/3 | 0/3 |
| Ileum | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 |
| Colon | 0/3 | 0/3 | 0/3 | 1/3 | 0/3 | 1/3 | 1/5 | 2/5 | 1/3 | 1/3 | 0/3 | 0/3 |
| Mesenteric LN | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 1/5 | 1/5 | 0/3 | 0/3 | 0/3 | 0/3 |
| Skin | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 1/5 | 1/4 | 0/3 | 0/2 | 1/4 | 1/3 |
| Inguinal LN | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 0/5 | 3/5 | 0/3 | 0/3 | 0/3 | 0/1 |
| Axillary LN | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 1/3 | 0/3 | 0/2 | 0/3 | 0/3 | 0/3 | 0/2 |
a
Lung RU, right upper lobe; lung RM, right middle lobe; lung RL, right lower lobe; lung LU, left upper lobe; lung LL, left lower lobe; LN, lymph node; H&E, hematoxylin and eosin; IHC, immunohistochemistry (to identify monkeypox virus antigens).